Recombinant Human/Mouse FGF-8b Protein (2024)

Recombinant Human/Mouse FGF-8b Protein Summary

Details of Functionality	Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is typically6.5-40 ng/mL in the presence of 1 µg/mL heparin.
Source	E. coli-derived FGF-8 protein Gln23-Arg215, with an N-terminal Met
Accession #	NP_006110 (human), NP_001159834 (mouse)
N-terminal Sequence	Met
Protein/Peptide Type	Recombinant Proteins
Gene	FGF8
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions	Bioactivity
Theoretical MW	22.5 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE	23 kDa, reducing conditions
Reviewed Applications	Read 1 Review rated 5 using 423-F8 in the following application: Stem/Immune cell maintenance or differentiation
Publications	Read Publications using 423-F8 in the following applications: Bioassay 43 publications Cell Culture 6 publications Differentiation 4 publications In Ovo 1 publication In Vivo 8 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in MOPS, Na₂SO₄ and Brij-35 with BSA as a carrier protein.
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human/Mouse FGF-8b Protein

AIGF
AIGFKAL6
Androgen-induced growth factor
FGF8
FGF-8
fibroblast growth factor 8 (androgen-induced)
fibroblast growth factor 8
HBGF-8
Heparin-binding growth factor 8
MGC149376

Background

FGF-8 is a member of the fibroblast growth factor family that was originally discovered as a growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells (1-3). Alternate splicing of mouse FGF-8 mRNA generates eight secreted isoforms, designated a-h, but only FGF-8a, b, e and f exist in humans (4). FGF-8 contains a 22 amino acid (aa) signal sequence, an N‑terminal domain that varies according to the isoform (30 aa for FGF-8b; 20 aa for the shortest, FGF-8a), a 125aa FGF domain and a 37 aa proline‑rich C‑terminal sequence. The FGF domain of FGF-8 shares the most aa identity with FGF17 (75%)and FGF-18 (67%), and the three form an FGF subfamily (2). Mouse FGF-8b shares 100% aa identity with human FGF-8b. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an organizing and inducing role during gastrulation, and regulates patterning of the midbrain/hindbrain, eye, ear, limbs and heart in the embryo (2,5-8). The isoforms may play different roles in development. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity although FGF-8a andFGF-8e are also transforming and have been found in human prostate, breast or ovarian tumors (1,5,9-12). FGF-8 shows limited expression in the normal adult, but low levels are found in the reproductive and genitourinary tract, peripheral leukocytes and bone marrow hematopoietic cells (3,9,13).

Mattila, M.M.and P.L. Harkonen (2007) Cytokine Growth Factor Rev. 18:257.
Reuss, B.and O. von Bohlen und Halbach (2003) Cell Tiss. Res. 313:139.
Tanaka, A. et al. (1992) Proc. Natl. Acad. Sci. USA 89:8928.
Gemel, J. et al. (1996) Genomics 35:253.
Olsen, S.K. et al. (2006) Genes Dev. 20:185.
Crossley, P.H. et al. (1996) Cell, 84:127.
Heikinheimo, M. et al. (1994) Mech. Dev. 48:129.
Sun, X. et al. (1999) Genes Dev. 13:1834.
Ghosh, A.K. et al. (1996) Cell Growth Differ. 7:1425.
Mattila, M.M. et al. (2001) Oncogene 20:2791.
Valve, E. et al. (2000) Int. J. Cancer 88:718.
Valve, E.M. et al. (2001) Lab. Invest. 81:815.
Nezu, M. et al. (2005) Biochem. Biophys. Res. Commun. 335:843.

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Publications for FGF-8 (423-F8)(60)

We have publications tested in 9 confirmed species: Human, Mouse, Rat, Avian - Quail, Chicken, Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Xenopus, Zebrafish.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, In Ovo, In Vivo.

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Bioassay

(43)

Cell Culture

(6)

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(4)

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(1)

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(8)

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(27)

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(15)

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(4)

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(1)

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(8)

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(1)

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(1)

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(2)

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Showing Publications 1 - 10 of 60. Show All 60 Publications.

Publications using 423-F8	Applications	Species
Chen, Y;Kuang, J;Niu, Y;Zhu, H;Chen, X;So, KF;Xu, A;Shi, L; Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons Neural regeneration research 2024-04-01 [PMID: 37843228] (Bioassay, Human)	Bioassay	Human
S Wu, NC Hernandez, DW Sirkis, I Thomas-Wri, R Wade-Marti, R Schekman Unconventional secretion of alpha-synuclein mediated by palmitoylated DNAJC5 oligomers Elife, 2023-01-10;12(0):. 2023-01-10 [PMID: 36626307] (Bioassay, Mouse)	Bioassay	Mouse
CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F fa*ghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (Bioassay, Human)	Bioassay	Human
JS Park, J Choi, L Cao, J Mohanty, Y Suzuki, A Park, D Baker, J Schlessing, S Lee Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein Cell Reports, 2022-10-25;41(4):111545. 2022-10-25 [PMID: 36288716] (Bioassay, Human)	Bioassay	Human
H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state Scientific Reports, 2022-10-17;12(1):17381. 2022-10-17 [PMID: 36253431] (Cell Culture, Human)	Cell Culture	Human
DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells Stem Cells International, 2022-09-27;2022(0):1092184. 2022-09-27 [PMID: 36213683] (Cell Culture, Mouse)	Cell Culture	Mouse
L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P Härkönen Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression Cancers, 2022-01-07;14(2):. 2022-01-07 [PMID: 35053442] (Bioassay, Human)	Bioassay	Human
N Hosaka, S Kanda, T Shimono, T Nishiyama Induction of gammadeltaT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells Journal of Cellular and Molecular Medicine, 2021-10-23;0(0):. 2021-10-23 [PMID: 34687276] (Cell Culture, Mouse)	Cell Culture	Mouse
M Restan Per, R Sharma, NZ Masri, SM Willerth 3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink Biomolecules, 2021-08-21;11(8):. 2021-08-21 [PMID: 34439916] (Bioassay, Human)	Bioassay	Human
C Zhou, D Chen, J Ren, D Huang, R Li, H Luo, C Guan, Y Cao, W Wang FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex Journal of Cellular and Molecular Medicine, 2021-02-13;0(0):. 2021-02-13 [PMID: 33580754] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use Cell Stem Cell, 2021-02-04;28(2):343-355.e5. 2021-02-04 [PMID: 33545081] (Bioassay, Human)	Bioassay	Human
T Otsuka, PY Mengsteab, CT Laurencin Control of mesenchymal cell fate via application of FGF-8b in vitro Stem Cell Research, 2021-01-07;51(0):102155. 2021-01-07 [PMID: 33445073] (Bioassay, Rat)	Bioassay	Rat
KX Liang, CK Kristianse, S Mostafavi, GH Vatne, GA Zantingh, A Kianian, C Tzoulis, LE Høyland, M Ziegler, RM Perez, J Furriol, Z Zhang, N Balafkan, Y Hong, R Siller, GJ Sullivan, LA Bindoff Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations EMBO Mol Med, 2020-08-25;0(0):e12146. 2020-08-25 [PMID: 32840960] (Bioassay, Human)	Bioassay	Human
JL Goggi, L Qiu, MC Liao, S Khanapur, L Jiang, R Boominatha, SV Hartimath, P Cheng, FF Yong, V Soh, X Deng, YM Lin, A Haslop, PW Tan, X Zeng, JWL Lee, Z Zhang, P Sadasivam, EK Tan, SK Luthra, WD Shingleton, SKW Oh, L Zeng, EG Robins Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease Stem Cell Res Ther, 2020-08-08;11(1):347. 2020-08-08 [PMID: 32771055] (Bioassay, Human)	Bioassay	Human
H Gla beta , P Neumann, A Pal, P Reinhardt, A Storch, J Sternecker, A Hermann Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis Int J Mol Sci, 2020-03-05;21(5):. 2020-03-05 [PMID: 32151030] (Cell Culture, Human)	Cell Culture	Human
S Mahajani, A Raina, C Fokken, S Kügler, M Bähr hom*ogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors Cell Death Dis, 2019-11-27;10(12):898. 2019-11-27 [PMID: 31776327] (Cell Culture, Human)	Cell Culture	Human
S Westphal, T Gantert, C Kless, K Hüttinger, M Klingenspo, T Fromme Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes Sci Rep, 2019-06-11;9(1):8470. 2019-06-11 [PMID: 31186471] (Bioassay, Mouse)	Bioassay	Mouse
I Allodi, J Nijssen, JA Benitez, C Schweingru, A Fuchs, G Bonvicini, M Cao, O Kiehn, E Hedlund Modeling Motor Neuron Resilience in ALS Using Stem Cells Stem Cell Reports, 2019-05-09;0(0):. 2019-05-09 [PMID: 31080111] (Bioassay, Mouse)	Bioassay	Mouse
M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients Front Cell Neurosci, 2019-02-22;13(0):58. 2019-02-22 [PMID: 30853899] (Bioassay, Human)	Bioassay	Human
G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons Front Pharmacol, 2018-06-01;9(0):572. 2018-06-01 [PMID: 29910731] (Bioassay, Human)	Bioassay	Human
J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018-06-13;0(0):9636897187803. 2018-06-13 [PMID: 29895168] (Bioassay, Human)	Bioassay	Human
X Hu, JW Lee, X Zheng, J Zhang, X Lin, Y Song, B Wang, X Hu, HH Chang, Y Chen, CP Lin, Y Zhang Efficient induction of functional ameloblasts from human keratinocyte stem cells Stem Cell Res Ther, 2018-05-02;9(1):126. 2018-05-02 [PMID: 29720250] (Bioassay, Human)	Bioassay	Human
G Collo, L Cavalleri, F Bono, C Mora, S Fedele, RW Invernizzi, M Gennarelli, G Piovani, T Kunath, MJ Millan, E Merlo Pich, P Spano Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling Neural Plast., 2018-02-04;2018(0):4196961. 2018-02-04 [PMID: 29531524] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
G Shall, M Menosky, S Decker, P Nethala, R Welchko, X Leveque, M Lu, M Sandstrom, U Hochgeschw, J Rossignol, G Dunbar Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells Int J Mol Sci, 2018-03-02;19(3):. 2018-03-02 [PMID: 29498713] (Bioassay, Rat)	Bioassay	Rat
A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou Chromosomal instability during neurogenesis in Huntington's disease Development, 2018-01-29;145(2):. 2018-01-29 [PMID: 29378824] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
T Johansen, C Krabbe, SI Schmidt, AM Serrano, M Meyer Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells Stem Cells Int, 2017-10-22;2017(0):9605432. 2017-10-22 [PMID: 29201062] (Bioassay, Human)	Bioassay	Human
AR Rodrigues, N Yakushiji-, Y Atsuta, G Andrey, P Schorderet, D Duboule, CJ Tabin Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;0(0):. 2017-03-07 [PMID: 28270602] (Bioassay, Chicken)	Bioassay	Chicken
SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres Neurotoxic reactive astrocytes are induced by activated microglia Nature, 2017-01-18;541(7638):481-487. 2017-01-18 [PMID: 28099414] (Bioassay, Human)	Bioassay	Human
Florian Wegner Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization J. Neurosci., 2016-11-23;36(47):12027-12043. 2016-11-23 [PMID: 27881786] (Bioassay, Human)	Bioassay	Human
Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: Effects on Embryo Survival J Biol Chem, 2016-07-08;0(0):. 2016-07-08 [PMID: 27402846] (Bioassay, Human)	Bioassay	Human
Daniel A Monti N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data PLoS ONE, 2016-06-16;11(6):e0157602. 2016-06-16 [PMID: 27309537] (Bioassay, Human)	Bioassay	Human
Eva Hedlund Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors Sci Rep, 2016-06-01;6(0):26448. 2016-06-01 [PMID: 27246266] (Bioassay, Mouse)	Bioassay	Mouse
Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, Pratt T 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS ONE, 2015-06-15;10(6):e0130147. 2015-06-15 [PMID: 26075383] (Bioassay, Mouse)	Bioassay	Mouse
Shen , Shih-Che, Shen , Ching-I, Lin , Ho, Chen , Chun-Jun, Chang , Chia-Yu, Chen , Sheng-Me, Lee , Hsiu-Chi, Lai , Ping-Sha, Su , Hong-Lin Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection. PLoS ONE, 2014-12-17;9(12):e114990. 2014-12-17 [PMID: 25517725] (Bioassay, Human)	Bioassay	Human
Attia L, Schneider J, Yelin R, Schultheiss T Collective cell migration of the nephric duct requires FGF signaling. Dev Dyn, 2014-12-30;244(2):157-67. 2014-12-30 [PMID: 25516335] (Bioassay, Chicken)	Bioassay	Chicken
Yamamoto-Shiraishi Y, Higuchi H, Yamamoto S, Hirano M, Kuroiwa A Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal. Dev Biol, 2014-08-07;394(1):181-90. 2014-08-07 [PMID: 25109552] (Bioassay, Chicken)	Bioassay	Chicken
Lewandowski J, Pursell T, Rabinowitz A, Vokes S Manipulating gene expression and signaling activity in cultured mouse limb bud cells. Dev Dyn, 2014-04-17;243(7):928-36. 2014-04-17 [PMID: 24633820] (Bioassay, Mouse)	Bioassay	Mouse
Mong J, Panman L, Alekseenko Z, Kee N, Stanton L, Ericson J, Perlmann T Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells. Stem Cells, 2014-03-01;32(3):609-22. 2014-03-01 [PMID: 24549637] (Bioassay, Mouse)	Bioassay	Mouse
Ni , Na, Hu , Yaohua, Ren , Huixia, Luo , Chuanmin, Li , Peng, Wan , Jian-Bo, Su , Huanxing Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. PLoS ONE, 2013-12-20;8(12):e84504. 2013-12-20 [PMID: 24376815] (Bioassay, Mouse)	Bioassay	Mouse
McCarroll , Matthew, Nechiporuk , Alex V Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PLoS ONE, 2013-12-17;8(12):e85087. 2013-12-17 [PMID: 24358375] (In Vivo, Zebrafish)	In Vivo	Zebrafish
Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE, 2013-03-18;8(3):e59011. 2013-03-18 [PMID: 23527072] (Bioassay, Human)	Bioassay	Human
Tomlinson DC, Knowles MA Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am. J. Pathol., 2010-10-01;177(5):2379-86. 2010-10-01 [PMID: 20889570] (Bioassay, Human)	Bioassay	Human
Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Rat)	Cell Culture	Rat
Nimmagadda S, Geetha-Loganathan P, Scaal M, Christ B, Huang R FGFs, Wnts and BMPs mediate induction of VEGFR-2 (Quek-1) expression during avian somite development. Dev. Biol., 2007-03-01;305(2):421-9. 2007-03-01 [PMID: 17425953] (In Vivo, Avian - Quail)	In Vivo	Avian - Quail
Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002. 2007-02-09 [PMID: 17293457] (Bioassay, Mouse)	Bioassay	Mouse
Shimizu T, Bae YK, Hibi M Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development, 2006-11-01;133(23):4709-19. 2006-11-01 [PMID: 17079270] (Bioassay, Zebrafish)	Bioassay	Zebrafish
Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-08-30;133(19):3787-96. 2006-08-30 [PMID: 16943279] (Bioassay, Mouse)	Bioassay	Mouse
Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev. Biol., 2006-07-12;298(2):585-96. 2006-07-12 [PMID: 16904661] (In Vivo, Chicken)	In Vivo	Chicken
Yamash*ta H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death. J. Neurochem., 2006-07-01;98(1):45-56. 2006-07-01 [PMID: 16805795] (Bioassay, Mouse)	Bioassay	Mouse
Hutson MR, Zhang P, Stadt HA, Sato AK, Li YX, Burch J, Creazzo TL, Kirby ML Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Dev. Biol., 2006-06-12;295(2):486-97. 2006-06-12 [PMID: 16765936] (Bioassay, Chicken)	Bioassay	Chicken
Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci., 2005-10-21;31(2):251-62. 2005-10-21 [PMID: 16243537] (Bioassay, Rat)	Bioassay	Rat
Delfini MC, Dubrulle J, Malapert P, Chal J, Pourquie O Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc. Natl. Acad. Sci. U.S.A., 2005-07-29;102(32):11343-8. 2005-07-29 [PMID: 16055560] (In Vivo, Chicken)	In Vivo	Chicken
Reversade B, Kuroda H, Lee H, Mays A, De Robertis EM Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development, 2005-06-23;132(15):3381-92. 2005-06-23 [PMID: 15975940] (In Vivo, Xenopus)	In Vivo	Xenopus
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8. 2004-08-13 [PMID: 15310843] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Wiellette EL, Sive H vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Development, 2003-08-01;130(16):3821-9. 2003-08-01 [PMID: 12835397] (In Vivo, Zebrafish)	In Vivo	Zebrafish
Gunhaga L, Marklund M, Sjodal M, Hsieh JC, Jessell TM, Edlund T Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat. Neurosci., 2003-07-01;6(7):701-7. 2003-07-01 [PMID: 12766771] (Bioassay, Chicken)	Bioassay	Chicken
Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int. J. Dev. Biol., 2003-02-01;47(1):15-29. 2003-02-01 [PMID: 12653248] (In Vivo, Xenopus)	In Vivo	Xenopus
Fischer A, Viebahn C, Blum M FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr. Biol., 2002-10-29;12(21):1807-16. 2002-10-29 [PMID: 12419180] (Bioassay, Rabbit)	Bioassay	Rabbit
Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development, 2002-10-01;129(19):4613-25. 2002-10-01 [PMID: 12223417] (In Vivo, Mouse)	In Vivo	Mouse
Alsan BH, 2019, Schultheiss TM Regulation of avian cardiogenesis by Fgf8 signaling. e0007247, 2002-04-01;129(8):1935-43. 2002-04-01 [PMID: 11934859] (In Ovo, Chicken)	In Ovo	Chicken
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Review for FGF-8 (423-F8) (1)

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Stem/Immune cell maintenance or differentiation

09/11/2019

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Application	Stem/Immune cell maintenance or differentiation
Lot	AFK2714121
Comments	Used for differentiation of human iPSC to dopaminergic neurons. easy to reconstitute and wasn't toxic to cells.

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Recombinant Human/Mouse FGF-8b Protein (2024)

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Publications for FGF-8 (423-F8)(60)

Review for FGF-8 (423-F8) (1)

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